SARS-CoV-2 (COVID-19) Genome
Complete genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolate Wuhan-Hu-1, also known as COVID-19.
Explore Over 2.7k Plasmids: Coronavirus Resources | More Plasmid Sets
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After cleavage, BseYI can remain bound to DNA and alter its electrophoretic mobility. |
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PaeR7I does not recognize the sequence CTCTCGAG. |
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This recognition sequence is asymmetric, so ligating blunt ends generated by BsrBI will not always regenerate a BsrBI site.BsrBI is typically used at 37°C, but can be used at temperatures up to 50°C. |
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Efficient cleavage requires at least two copies of the SgrAI recognition sequence. |
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After cleavage, BamHI-HF® (but not the original BamHI) can remain bound to DNA and alter its electrophoretic mobility. |
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SwaI is typically used at 25°C, but is 50% active at 37°C. |
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Efficient cleavage requires at least two copies of the NaeI recognition sequence. |
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Efficient cleavage requires at least two copies of the NgoMIV recognition sequence. |
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SmaI can be used at 37°C for brief incubations. |
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Cleavage may be enhanced when more than one copy of the XmaI recognition sequence is present. |
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Sticky ends from different BglI sites may not be compatible. |
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Efficient cleavage requires at least two copies of the PluTI recognition sequence. |
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Efficient cleavage requires at least two copies of the NarI recognition sequence. |
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BsaHI is typically used at 37°C, but is even more active at 60°C. |
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Sticky ends from different TaqII sites may not be compatible. |
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| 5' UTR 1 .. 265 = 265 bp |
| 5' UTR 1 .. 265 = 265 bp |
| orf1ab 266 .. 21,555 = 21,290 bp 7096 amino acids = 794.1 kDa 2 segments Segment 1: 266 .. 13,468 = 13,203 bp 4401 amino acids = 489.6 kDa Product: orf1ab polyprotein pp1ab; translated by -1 ribosomal frameshift |
| orf1ab 266 .. 21,555 = 21,290 bp 7096 amino acids = 794.1 kDa 2 segments Segment 2: 13,468 .. 21,555 = 8088 bp 2695 amino acids = 304.5 kDa Product: orf1ab polyprotein pp1ab; translated by -1 ribosomal frameshift |
| orf1ab 266 .. 21,555 = 21,290 bp 7096 amino acids = 794.1 kDa 2 segments Product: orf1ab polyprotein pp1ab; translated by -1 ribosomal frameshift |
| S 21,563 .. 25,384 = 3822 bp 1273 amino acids = 141.2 kDa Product: surface glycoprotein structural protein; spike protein |
| S 21,563 .. 25,384 = 3822 bp 1273 amino acids = 141.2 kDa Product: surface glycoprotein structural protein; spike protein |
| ORF3a 25,393 .. 26,220 = 828 bp 275 amino acids = 31.1 kDa Product: ORF3a protein |
| ORF3a 25,393 .. 26,220 = 828 bp 275 amino acids = 31.1 kDa Product: ORF3a protein |
| E 26,245 .. 26,472 = 228 bp 75 amino acids = 8.4 kDa Product: envelope protein ORF4; structural protein; E protein |
| E 26,245 .. 26,472 = 228 bp 75 amino acids = 8.4 kDa Product: envelope protein ORF4; structural protein; E protein |
| M 26,523 .. 27,191 = 669 bp 222 amino acids = 25.1 kDa Product: membrane glycoprotein ORF5; structural protein |
| M 26,523 .. 27,191 = 669 bp 222 amino acids = 25.1 kDa Product: membrane glycoprotein ORF5; structural protein |
| ORF6 27,202 .. 27,387 = 186 bp 61 amino acids = 7.3 kDa Product: ORF6 protein |
| ORF6 27,202 .. 27,387 = 186 bp 61 amino acids = 7.3 kDa Product: ORF6 protein |
| ORF7a 27,394 .. 27,759 = 366 bp 121 amino acids = 13.7 kDa Product: ORF7a protein |
| ORF7a 27,394 .. 27,759 = 366 bp 121 amino acids = 13.7 kDa Product: ORF7a protein |
| ORF8 27,894 .. 28,259 = 366 bp 121 amino acids = 13.8 kDa Product: ORF8 protein |
| ORF8 27,894 .. 28,259 = 366 bp 121 amino acids = 13.8 kDa Product: ORF8 protein |
| N 28,274 .. 29,533 = 1260 bp 419 amino acids = 45.6 kDa Product: nucleocapsid phosphoprotein ORF9; structural protein |
| N 28,274 .. 29,533 = 1260 bp 419 amino acids = 45.6 kDa Product: nucleocapsid phosphoprotein ORF9; structural protein |
| ORF10 29,558 .. 29,674 = 117 bp 38 amino acids = 4.4 kDa Product: ORF10 protein |
| ORF10 29,558 .. 29,674 = 117 bp 38 amino acids = 4.4 kDa Product: ORF10 protein |
| 3' UTR 29,675 .. 29,903 = 229 bp |
| 3' UTR 29,675 .. 29,903 = 229 bp |
| orf1ab 266 .. 13,483 = 13,218 bp 4405 amino acids = 490.0 kDa Product: orf1a polyprotein pp1a |
| orf1ab 266 .. 13,483 = 13,218 bp 4405 amino acids = 490.0 kDa Product: orf1a polyprotein pp1a |
| stem loop 13,488 .. 13,542 = 55 bp Function: Coronavirus frameshifting stimulation element stem-loop 2 |
| stem loop 13,488 .. 13,542 = 55 bp Function: Coronavirus frameshifting stimulation element stem-loop 2 |
| mature peptide 16,237 .. 18,039 = 1803 bp Product: helicase nsp13_ZBD, nsp13_TB, and nsp_HEL1core; zinc-binding domain (ZD), NTPase/helicase domain (HEL), RNA 5'-triphosphatase; produced by pp1ab only /protein_id=YP_009725308.1 |
| mature peptide 16,237 .. 18,039 = 1803 bp Product: helicase nsp13_ZBD, nsp13_TB, and nsp_HEL1core; zinc-binding domain (ZD), NTPase/helicase domain (HEL), RNA 5'-triphosphatase; produced by pp1ab only /protein_id=YP_009725308.1 |
| mature peptide 18,040 .. 19,620 = 1581 bp Product: 3'-to-5' exonuclease nsp14A2_ExoN and nsp14B_NMT; produced by pp1ab only /protein_id=YP_009725309.1 |
| mature peptide 18,040 .. 19,620 = 1581 bp Product: 3'-to-5' exonuclease nsp14A2_ExoN and nsp14B_NMT; produced by pp1ab only /protein_id=YP_009725309.1 |
| mature peptide 19,621 .. 20,658 = 1038 bp Product: endoRNAse nsp15-A1 and nsp15B-NendoU; produced by pp1ab only /protein_id=YP_009725310.1 |
| mature peptide 19,621 .. 20,658 = 1038 bp Product: endoRNAse nsp15-A1 and nsp15B-NendoU; produced by pp1ab only /protein_id=YP_009725310.1 |
| mature peptide 20,659 .. 21,552 = 894 bp Product: 2'-O-ribose methyltransferase nsp16_OMT; 2'-o-MT; produced by pp1ab only /protein_id=YP_009725311.1 |
| mature peptide 20,659 .. 21,552 = 894 bp Product: 2'-O-ribose methyltransferase nsp16_OMT; 2'-o-MT; produced by pp1ab only /protein_id=YP_009725311.1 |
| ORF7b 27,756 .. 27,887 = 132 bp 43 amino acids = 5.2 kDa Product: ORF7b |
| ORF7b 27,756 .. 27,887 = 132 bp 43 amino acids = 5.2 kDa Product: ORF7b |
| stem loop 29,609 .. 29,644 = 36 bp Function: Coronavirus 3' UTR pseudoknot stem-loop 1 |
| stem loop 29,609 .. 29,644 = 36 bp Function: Coronavirus 3' UTR pseudoknot stem-loop 1 |
| stem loop 29,728 .. 29,768 = 41 bp Function: Coronavirus 3' stem-loop II-like motif (s2m) basepair exception: alignment to the Rfam model implies coordinates 29740:29758 form a noncanonical C:T basepair, but the homologous positions form a highly conserved C:G basepair in other viruses, including SARS (NC_004718.3) |
| stem loop 29,728 .. 29,768 = 41 bp Function: Coronavirus 3' stem-loop II-like motif (s2m) basepair exception: alignment to the Rfam model implies coordinates 29740:29758 form a noncanonical C:T basepair, but the homologous positions form a highly conserved C:G basepair in other viruses, including SARS (NC_004718.3) |
| mature peptide 266 .. 805 = 540 bp Product: leader protein nsp1; produced by both pp1a and pp1ab /protein_id=YP_009725297.1 |
| mature peptide 266 .. 805 = 540 bp Product: leader protein nsp1; produced by both pp1a and pp1ab /protein_id=YP_009725297.1 |
| mature peptide 806 .. 2719 = 1914 bp Product: nsp2 produced by both pp1a and pp1ab /protein_id=YP_009725298.1 |
| mature peptide 806 .. 2719 = 1914 bp Product: nsp2 produced by both pp1a and pp1ab /protein_id=YP_009725298.1 |
| mature peptide 2720 .. 8554 = 5835 bp Product: nsp3 former nsp1; conserved domains are: N-terminal acidic (Ac), predicted phosphoesterase, papain-like proteinase, Y-domain, transmembrane domain 1 (TM1), adenosine diphosphate-ribose 1''-phosphatase (ADRP); produced by both pp1a and pp1ab /protein_id=YP_009725299.1 |
| mature peptide 2720 .. 8554 = 5835 bp Product: nsp3 former nsp1; conserved domains are: N-terminal acidic (Ac), predicted phosphoesterase, papain-like proteinase, Y-domain, transmembrane domain 1 (TM1), adenosine diphosphate-ribose 1''-phosphatase (ADRP); produced by both pp1a and pp1ab /protein_id=YP_009725299.1 |
| mature peptide 8555 .. 10,054 = 1500 bp Product: nsp4 nsp4B_TM; contains transmembrane domain 2 (TM2); produced by both pp1a and pp1ab /protein_id=YP_009725300.1 |
| mature peptide 8555 .. 10,054 = 1500 bp Product: nsp4 nsp4B_TM; contains transmembrane domain 2 (TM2); produced by both pp1a and pp1ab /protein_id=YP_009725300.1 |
| mature peptide 10,055 .. 10,972 = 918 bp Product: 3C-like proteinase nsp5A_3CLpro and nsp5B_3CLpro; main proteinase (Mpro); mediates cleavages downstream of nsp4. 3D structure of the SARSr-CoV homolog has been determined (Yang et al., 2003); produced by both pp1a and pp1ab /protein_id=YP_009725301.1 |
| mature peptide 10,055 .. 10,972 = 918 bp Product: 3C-like proteinase nsp5A_3CLpro and nsp5B_3CLpro; main proteinase (Mpro); mediates cleavages downstream of nsp4. 3D structure of the SARSr-CoV homolog has been determined (Yang et al., 2003); produced by both pp1a and pp1ab /protein_id=YP_009725301.1 |
| mature peptide 10,973 .. 11,842 = 870 bp Product: nsp6 nsp6_TM; putative transmembrane domain; produced by both pp1a and pp1ab /protein_id=YP_009725302.1 |
| mature peptide 10,973 .. 11,842 = 870 bp Product: nsp6 nsp6_TM; putative transmembrane domain; produced by both pp1a and pp1ab /protein_id=YP_009725302.1 |
| mature peptide 11,843 .. 12,091 = 249 bp Product: nsp7 produced by both pp1a and pp1ab /protein_id=YP_009725303.1 |
| mature peptide 11,843 .. 12,091 = 249 bp Product: nsp7 produced by both pp1a and pp1ab /protein_id=YP_009725303.1 |
| mature peptide 12,092 .. 12,685 = 594 bp Product: nsp8 produced by both pp1a and pp1ab /protein_id=YP_009725304.1 |
| mature peptide 12,092 .. 12,685 = 594 bp Product: nsp8 produced by both pp1a and pp1ab /protein_id=YP_009725304.1 |
| mature peptide 12,686 .. 13,024 = 339 bp Product: nsp9 ssRNA-binding protein; produced by both pp1a and pp1ab /protein_id=YP_009725305.1 |
| mature peptide 12,686 .. 13,024 = 339 bp Product: nsp9 ssRNA-binding protein; produced by both pp1a and pp1ab /protein_id=YP_009725305.1 |
| mature peptide 13,025 .. 13,441 = 417 bp Product: nsp10 nsp10_CysHis; formerly known as growth-factor-like protein (GFL); produced by both pp1a and pp1ab /protein_id=YP_009725306.1 |
| mature peptide 13,025 .. 13,441 = 417 bp Product: nsp10 nsp10_CysHis; formerly known as growth-factor-like protein (GFL); produced by both pp1a and pp1ab /protein_id=YP_009725306.1 |
| mature peptide 13,442 .. 16,236 = 2795 bp 2 segments Segment 1: 13,442 .. 13,468 = 27 bp Product: RNA-dependent RNA polymerase nsp12; NiRAN and RdRp; produced by pp1ab only /protein_id=YP_009725307.1 |
| mature peptide 13,442 .. 16,236 = 2795 bp 2 segments Segment 2: 13,468 .. 16,236 = 2769 bp Product: RNA-dependent RNA polymerase nsp12; NiRAN and RdRp; produced by pp1ab only /protein_id=YP_009725307.1 |
| mature peptide 13,442 .. 16,236 = 2795 bp 2 segments Product: RNA-dependent RNA polymerase nsp12; NiRAN and RdRp; produced by pp1ab only /protein_id=YP_009725307.1 |
| stem loop 29,629 .. 29,657 = 29 bp Function: Coronavirus 3' UTR pseudoknot stem-loop 2 |
| stem loop 29,629 .. 29,657 = 29 bp Function: Coronavirus 3' UTR pseudoknot stem-loop 2 |
| mature peptide 13,442 .. 13,480 = 39 bp Product: nsp11 produced by pp1a only /protein_id=YP_009725312.1 |
| mature peptide 13,442 .. 13,480 = 39 bp Product: nsp11 produced by pp1a only /protein_id=YP_009725312.1 |
| stem loop 13,476 .. 13,503 = 28 bp Function: Coronavirus frameshifting stimulation element stem-loop 1 |
| stem loop 13,476 .. 13,503 = 28 bp Function: Coronavirus frameshifting stimulation element stem-loop 1 |
| ORF: 13,768 .. 21,555 = 7788 bp ORF: 2595 amino acids = 293.0 kDa |
| ORF: 25,393 .. 26,220 = 828 bp ORF: 275 amino acids = 31.1 kDa |
| ORF: 26,245 .. 26,472 = 228 bp ORF: 75 amino acids = 8.4 kDa |
| ORF: 27,394 .. 27,759 = 366 bp ORF: 121 amino acids = 13.7 kDa |
| ORF: 266 .. 13,483 = 13,218 bp ORF: 4405 amino acids = 490.0 kDa |
| ORF: 21,536 .. 25,384 = 3849 bp ORF: 1282 amino acids = 142.3 kDa |
| ORF: 28,274 .. 29,533 = 1260 bp ORF: 419 amino acids = 45.6 kDa |
| ORF: 2958 .. 3206 = 249 bp ORF: 82 amino acids = 9.6 kDa |
| ORF: 21,936 .. 22,199 = 264 bp ORF: 87 amino acids = 10.2 kDa |
| ORF: 26,523 .. 27,191 = 669 bp ORF: 222 amino acids = 25.1 kDa |
| ORF: 27,894 .. 28,259 = 366 bp ORF: 121 amino acids = 13.8 kDa |
| ORF: 28,284 .. 28,577 = 294 bp ORF: 97 amino acids = 10.8 kDa |
| ORF: 422 .. 667 = 246 bp ORF: 81 amino acids = 9.6 kDa |
| ORF: 23,198 .. 23,437 = 240 bp ORF: 79 amino acids = 9.1 kDa |
| ORF: 6187 .. 6489 = 303 bp ORF: 100 amino acids = 10.8 kDa |
| ORF: 23,074 .. 23,322 = 249 bp ORF: 82 amino acids = 8.9 kDa |
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